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4 p.

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Mechanisms of Development

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Sexual reproduction in the ciliate Tetrahymena follows a complex developmental program involving the sequential regulation of dozens of genes. Genes that are up-regulated during post-zygotic development in Tetrahymena were isolated by subtractive hybridization. Anlagen stage induced gene 1 (ASI1) encodes a 2.8 kb transcript that contains a single intron and is induced during macronuclear development. ASI1 is a single copy gene in both the micronucleus and the macronucleus. It encodes a 95 kDa conceptual protein with a leucine zipper near the amino terminus


Accepted version. Mechanisms of Development, Vol. 118, No. 1-2 (October 2002): 215-218. DOI. Published under Creative Commons License Attribution-Noncommercial-NoDerivs 4.0.

NOTICE: this is the author’s version of a work that was accepted for publication in Mechanisms of Development. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Mechanisms of Development, VOL 118, ISSUE 2, October 2002, DOI.

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