Title

Dragon's Blood May Have Radioprotective Effects in Radiation-Induced Rat Brain Injury

Document Type

Article

Language

eng

Format of Original

11 p.

Publication Date

2012

Publisher

Radiation Research Society

Source Publication

Radiation Research

Source ISSN

0033-7587

Abstract

Dragon's blood is a bright red resin obtained from Dracaena cochinchinensis. It is a traditional medicinal that is used for wound healing and to stop bleeding. Its main biological activity appears to be from phenolic compounds found in Dragon's blood. In this study, the radioprotective effects of Dragon's blood were examined after whole brain irradiation of rats with either 100 MeV/u Carbon 12C6+ heavy ions or 60Co γ-rays. The amounts of radiation-induced oxidative stress, inflammatory cytokines and apoptosis in irradiated rat brains were compared with and without Dragon's blood treatment. Compared to the “irradiation only” control group, the Dragon's blood treatment group significantly decreased malondialdehyde and hydrogen peroxide levels, and increased superoxide dismutase activity and glutathione levels induced by oxidative stress in radiation exposed rats (P < 0.05). Dragon's blood also significantly reduced radiation-induced inflammatory cytokines of tumor necrosis factor-α, interferon-γ and interleukin-6 levels (P < 0.05) and inhibited hippocampal neuronal apoptosis in 60Co γ-ray irradiated rats. Furthermore, Dragon's blood significantly increased expression of brain-derived neurophic factor and inhibited the expression of pro-apoptotic caspase 3 (P < 0.05–0.01). Finally, Dragon's blood significantly inhibited expression of the AP-1 transcription factor family members c-fos and c-jun proteins (P < 0.05–0.01). The results obtained here suggest that Dragon's blood has radioprotective properties in rat brains after both heavy ions and 60Co γ-ray exposure.

Comments

Radiation Research, Vol. 178, No. 1 (2012): 75-85. Permalink. © 2012 Radiation Research Society.