Document Type

Article

Language

eng

Format of Original

20 p.

Publication Date

7-2010

Publisher

Wiley

Source Publication

Molecular Reproduction and Development

Source ISSN

1040-452X

Abstract

Regulation of maturation in meiotically competent mammalian oocytes is a complex process involving the carefully coordinated exchange of signals between the somatic and germ cell compartments of the ovarian follicle via paracrine and cell–cell coupling pathways. This review highlights recent advances in our understanding of how such signaling controls both meiotic arrest and gonadotropin-triggered meiotic resumption in competent oocytes and relates them to the historical context. Emphasis will be on rodent systems, where many of these new findings have taken place. A regulatory scheme is then proposed that integrates this information into an overall framework for meiotic regulation that demonstrates the complex interplay between different follicular compartments.

Comments

Accepted version. Molecular Reproduction and Development, Vol. 77, No. 7 (July 2010): 566-585. DOI. © Wiley 2010. This article may be used for non-commercial purposes in accordance With Wiley Terms and Conditions for self-archiving.

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