Title

Immune-complex Disease in Guinea Pig Lungs: I. Elicitation by Aerosol Challenge, Suppression with Cobra Venom Factor, and Passive Transfer with Serum

Document Type

Article

Language

eng

Format of Original

12 p.

Publication Date

9-1977

Publisher

Elsevier

Source Publication

Clinical Immunology and Immunopathology

Source ISSN

0090-1229

Abstract

Immune-complex disease was elicited in the lungs of ovalbumin-sensitized guinea pigs following an aerosol challenge with specific antigen. An acute inflammatory reaction, characterized by peribronchial polymorphonuclear leukocyte infiltration, edema, and hemorrhage, was observed 2 hr following aerosol challenge. This focal reaction developed into a diffuse reaction within 6 to 12 hr postchallenge. By 24 hr postchallenge, the acute inflammatory process had begun to resolve. The active disease was suppressed with cobra venom factor and was transferred to normal guinea pigs with immune serum.

Comments

Clinical Immunology and Immunopathology, Vol. 8, No. 2 (September 1977): 213-224. DOI.