Document Type

Article

Language

eng

Format of Original

19 p.

Publication Date

2010

Publisher

Bentham Open

Source Publication

The Open Enzyme Inhibition Journal

Source ISSN

1874-9402

Abstract

This review aims to discuss the varied types of inhibitors of biotin-dependent carboxylases, with an emphasis on the inhibitors of pyruvate carboxylase. Some of these inhibitors are physiologically relevant, in that they provide ways of regulating the cellular activities of the enzymes e.g. aspartate and prohibitin inhibition of pyruvate carboxylase. Most of the inhibitors that will be discussed have been used to probe various aspects of the structure and function of these enzymes. They target particular parts of the structure e.g. avidin – biotin, FTP – ATP binding site, oxamate – pyruvate binding site, phosphonoacetate – binding site of the putative carboxyphosphate intermediate.

Comments

Published version. The Open Enzyme Inhibition Journal, Vol. 3 (2010): 8-26. DOI. © Bentham Open 2010. Used with permission.

This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/)

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