Document Type

Article

Language

eng

Format of Original

1 p.

Publication Date

6-1971

Publisher

National Academy of Sciences

Source Publication

Proceedings of the National Academy of Sciences

Source ISSN

0027-8424

Abstract

Two morphactins and three aminofluorenes initiated the formation of compact tissue nodules in hormone-dependent tobacco callus cultures. These nodules, upon subculture, behaved like partially transformed plant tumors. They grew on cytokinin-free media, while control callus and nonnodule tissue still required an exogenous cytokinin source. The data indicate that substituted fluorenes, including carcinogenic aminofluorenes, can cause a neoplastic growth response in cultured tobacco tissues. Of particular interest in this study is the finding that a directed and heritable cellular change is induced in tobacco tissue in which a specific (the endogenous cytokinin) biosynthetic system is regularly and persistently activated.

Comments

Published version. Proceedings of the National Academy of Sciences, Vol. 68, No. 6 (June 1971): 1178-1179. Permalink. © National Academy of Sciences 1971. Used with permission.

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