Document Type

Article

Language

eng

Publication Date

2016

Publisher

Cold Spring Harbor Laboratory Press

Source Publication

Cold Spring Harbor Perspectives in Biology

Source ISSN

1943-0264

Original Item ID

DOI: 10.1101/cshperspect.a028126, PMID: 27940518

Abstract

Propulsive forces generated by cilia and flagella are used in events that are critical for the thriving of diverse eukaryotic organisms in their environments. Despite distinctive strokes and regulations, the majority of them adopt the 9+2 axoneme that is believed to exist in the last eukaryotic common ancestor. Only a few outliers have opted for a simpler format that forsakes the signature radial spokes and the central pair apparatus, although both are unnecessary for force generation or rhythmicity. Extensive evidence has shown that they operate as an integral system for motility control. Recent studies have made remarkable progress on the radial spoke. This review will trace how the new structural, compositional, and evolutional insights pose significant implications on flagella biology and, conversely, ciliopathy.

Comments

Published version. Cold Harbor Perspectives in Biology (2016). © Cold Spring Harbor Laboratory Press 2016. DOI. Used with permission.

Available for download on Saturday, December 09, 2017

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