Title

Dragon's Blood extract has antithrombotic properties, affecting platelet aggregation functions and anticoagulation activities

Document Type

Article

Language

eng

Format of Original

5 p.

Publication Date

4-2011

Publisher

Elsevier

Source Publication

Journal of Ethnopharmacology

Source ISSN

0378-8741

Abstract

Ethnopharmacological relevance

Dragon's Blood from Dracaena cochinchinensis (Lour.) S.C. Chen (Yunnan, China), as a traditional Chinese medicinal herb, was shown to have certain antithrombotic effects. A new preparation process was used to extract effective components from Dragon's Blood. A 95% ethanol extract A (EA) and a precipitate B (PB) fraction were obtained and compared. Reliability of the preparation process was validated by pharmacodynamic experiments.

Materials and methods

A rat/mouse thrombosis and blood stasis model was developed for this study, and EA and PB effects on thrombosis, platelet functions and blood coagulation activities were analyzed.

Results

It was observed that the EA fraction had significantly better inhibitory effects than the PB fraction on thrombosis (p < 0.05), platelet aggregation function (p < 0.01) and anticoagulation activity (p < 0.05–0.01).

Conclusions

The results obtained here showed that EA fraction from Dragon's Blood contained pharmacologically effective compounds with antithrombotic effects, partially improving platelet function and anticoagulation activity.

Comments

Journal of Ethnopharmacology, Volume 135, Issue 2, pp 510-514 (May 2011). DOI: 10.1016/j.jep.2011.03.063