Document Type
Contribution to Book
Language
eng
Format of Original
18 p.
Publication Date
2016
Publisher
Shriners Hospitals for Children - Chicago
Source Publication
Transitional Care in Osteogenesis Imperfecta: Advances in biology, Technology, and Clinical Practice
Source ISSN
9780615596143
Abstract
Bone fragility is a fundamental problem in individuals with osteogenesis imperfecta (OI). The mechanisms behind this fragility, however, are not yet well understood. Multiple factors appear to contribute to the increased fracture risk in OI. At the structural level, bone mass deficiency can result in increased stress levels within bones. The underlying mineral and collagen abnormalities that define OI are also believed to result in compromised material-level properties. The variability of collagen biochemical irregularities causing OI and the corresponding heterogeneity of disease severity result in abnormalities that are not easily generalized within the OI population.
The aims of this chapter are to introduce basic mechanical notions pertaining to the strength of structures and materials, and to present a synthesis of existing literature regarding the mechanical properties of bones in OI.
Recommended Citation
Albert, Carolyne; Jameson, John; Smith, Peter; and Harris, Gerald F., "Material and Structural Aspects of Bone in Osteogenesis Imperfecta" (2016). Biomedical Engineering Faculty Research and Publications. 436.
https://epublications.marquette.edu/bioengin_fac/436
Comments
Published version. Transitional Care in Osteogenesis Imperfecta: Advances in biology, Technology, and Clinical Practice, (2016): pp. 177-194. Publisher link. © 2015 Shriners Hospitals for Children - Chicago. Used with permission.