Title

Influence of Chronic Naloxone Treatment on Development of Hypertension in the Spontaneously Hypertensive Rat

Document Type

Article

Language

eng

Format of Original

3 p.

Publication Date

1-1984

Publisher

Springer

Source Publication

Naunyn-Schmiedeberg's Archives of Pharmacology

Source ISSN

0028-1298

Original Item ID

doi: 10.1007/BF00507060

Abstract

Chronic administration of naloxone by means of miniosmotic pumps retarded the development of hypertension in young spontaneously hypertensive rats (SHRs) in a dose-related manner. Abrupt termination of naloxone treatment resulted in acceleration in the rate of the blood pressure increase, while increasing the naloxone concentration further slowed the development of hypertension in SHRs. The heart rates of SHRs undergoing chronic naloxone treatment were generally lower than those of control SHRs. Naloxone had no influence upon the mean systeolic blood pressures or heart rates of normotensive Wistar-Kyoto control rats. These findings indicate that chronic naloxone treatment can alter the development of hypertension in the SHR.

Comments

Naunyn-Schmiedeberg's Archives of Pharmacology, Vol. 325, No. 1 (January 1984): 88-90. DOI.