The Effect of Venous Blood Stream Cooling on Survival of Bacterially Infected Rabbits
Format of Original
Pflügers Archiv: European Journal of Physiology
Original Item ID
The effect of physical cooling on the mortality rate of rabbits infected withPasteurella multocida was investigated. Rabbits were colled for 48 hours after bacterial injection by passing cold fluid through small hollow metal cuffs which had been surgically implanted around the abdominal vena cavae of rabbits. The average body temperatures of the rabbits during the 24-hour period after the intravenous injection of livePasteurella multocida was 40.92±0.20°C in control rabbits and 38.98±0.71°C in cooled rabbits. 90% of physically cooled rabbits survived compared with 46% of control rabbits 48 hours after bacterial injection, suggesting that thermoregulatory effector mechanisms involved in cold defense may enhance survival.