Document Type
Article
Language
eng
Format of Original
9 p.
Publication Date
9-2010
Publisher
Korean Association of Anatomists
Source Publication
Anatomy & Cell Biology
Source ISSN
2093-3665
Original Item ID
doi: 10.5115/acb.2010.43.3.185
Abstract
We observed how the hypothyroid state affects diabetic states and modifies cell proliferation and neuroblast differentiation in the hippocampal dentate gyrus (DG). For this, 0.03% methimazole, an anti-thyroid drug, was administered to 7-week-old, pre-diabetic Zucker diabetic fatty (ZDF) rats by drinking water for 5 weeks, and the animals were sacrificed at 12 weeks of age. At this age, corticosterone levels were significantly increased in the ZDF rats compared to those in the control (Zucker lean control, ZLC) rats. Methimazole (methi) treatment in the ZDF rats (ZDF-methi rats) significantly decreased corticosterone levels and diabetes-induced hypertrophy of adrenal glands. In the DG, Ki67 (a marker for cell proliferation)- and doublecortin (DCX, a marker for neuronal progenitors)-immunoreactive cells were much lower in the ZDF rats than those in the ZLC rats. However, in ZDF-methi rats, numbers of Ki67- and DCX-immunoreactive cells were similar to those in the ZLC rats. These suggest that methi significantly reduces diabetes-induced hypertrophy of the adrenal gland and alleviates the diabetes-induced reduction of cell proliferation and neuronal progenitors in the DG.
Recommended Citation
Yi, Sun Shin; Hwang, In Koo; Choi, Ji Won; Won, Moo-Ho; Seong, Je Kyung; and Yoon, Yeo Sung, "Effects of Hypothyroidism on Cell Proliferation and Neuroblasts in the Hippocampal Dentate Gyrus in a Rat Model of Type 2 Diabetes" (2010). Biomedical Sciences Faculty Research and Publications. 83.
https://epublications.marquette.edu/biomedsci_fac/83
Comments
Published version. Anatomy & Cell Biology, Vol. 43, No. 3 (September 2010): 185-193. DOI. © 2010 Korean Association of Anatomists.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.