Document Type

Article

Publication Date

5-10-2013

Source Publication

Angewandte Chemie International Edition

Source ISSN

1433-7851

Abstract

Consequences of alternative H-bonding: Raman spectra of oxygenated intermediates of Nanodisc-incorporated human CYP17 in the presence of natural substrates (pregnenolone and progesterone) directly confirm that substrate structure effectively alters hydrogen-bonding interactions with the critical Fe–O–O fragment and dictates its predisposition for one of two alternative reaction pathways. Such substrate control has profound physiological implications.

Comments

Angewandte Chemie International Edition, Vol. 52, No. 20 (May 10, 2013): 5342-5345. DOI. © Wiley-VCH Verlag 2013. Used with permission.

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