Document Type

Article

Publication Date

10-2012

Source Publication

Angewandte Chemie International Edition

Source ISSN

1433-7851

Abstract

Resonance Raman spectroscopy is used to document, for the first time, a 6 cm−1 decrease of the Fe-S stretch by introducing an H-bond donor into the proximal pocket of a cytochrome P450, which interacts with the key cysteine thiolate axial ligand. The anticipated trans-effect on bound exogenous ligands is also confirmed and evidence is obtained supporting intimate interaction of the new histidyl-imidazole fragment with the heme periphery.

Comments

Accepted version. Angewandte Chemie International Edition, Vol. 51, No. 41 (October 2012): 10403–10407. DOI. © Wiley-VCH Verlag 2012. Used with permission.

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