Title

De novo synthesis of polyhydroxyl aminocyclohexanes

Document Type

Article

Publication Date

7-2010

Source Publication

Organic and Biomolecular Chemistry

Abstract

The syntheses of 12 stereochemically diverse polyhydroxyl aminocyclohexane (“aminocyclitols”) derivatives are described. These short syntheses require 2–5 steps from N-(2,4-cyclohexadien-1-yl)phthalimide, which is prepared in two steps from tricarbonyl(cyclohexadienyl)iron(1+). The relative stereochemistries of the aminocyclitols were assigned by 1H NMR spectroscopy as well as X-ray diffraction analysis.

Comments

Organic and Biomolecular Chemistry, 8 (2010), DOI: 10.1039/C004730A

supplemental_OBC8-2010.pdf (886 kB)
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