Electrochemistry of the Anticancer Agents Methotrexate and α-Difluaromethylornithine in lminium Form
Format of Original
Journal of Pharmaceutical Sciences
The electrochemical characteristics of the antitumor agents methotrexate and α-difluoromethylornithine were determined as their iminium derivatives. Iminium formation from methotrexate is accomplished in vivo via protonation by enzyme. The requisite imine precursor is generated from α-difluoromethylornithine by condensation with enzyme containing pyridoxal phosphate. Electroreduction occurs in the range of −0.2 to −0.6 V. The relationship of reduction to structure is discussed. A possible mode of anticancer action involving electron transfer is presented.