Title

Cyclic Voltammetry of Quinolinium Salts and Related Compounds: Correlation with Structure and Anticancer Activity

Document Type

Article

Language

eng

Format of Original

4 p.

Publication Date

6-1987

Publisher

Wiley

Source Publication

Journal of Pharmaceutical Sciences

Source ISSN

0022-3549

Abstract

Cyclic voltammetry data were obtained for 12 salts of quinolines, one pyridine, and one open-chain imine which possess varying degrees of anticancer activity. The structural features include sidechain bis(2-methylthio)vinyl, 2-methylthio-2-aminovinyl, dithioacetic acid, 2-quinolylvinyl, 2-styrylvinyl, and guanidine sulfide functionalities. Reduction potentials ranged from −0.43 to −1.08 V. The electrochemical results are correlated with structure. A possible mechanism of anticancer action is addressed.

Comments

Journal of Pharmaceutical Sciences, Vol. 76, No. 6 (June 1987): 481-484. DOI.