Title

A short synthesis of the common dihydropyran segment of the antifungal agents ambruticin and jerangolid A

Document Type

Article

Publication Date

8-2005

Source Publication

Tetrahedron Letters

Abstract

The dihydropyranyl segment common to ambruticin and jerangolid A was prepared in six steps (31.7% yield) from (S)-2-benzyloxypropanal via silyloxydiene cyclocondensation, followed by C-glycosidation, and eventual epimerization at C18.

Comments

Tetrahedron Letters, Vol. 46, No. 33 (August 2005) pp. 5529-5531. DOI: 10.1016/j.tetlet.2005.06.040