Title

Ruthenium-Catalyzed Hydrovinylation of Dienoates: Model Studies Directed Toward the C10—C18 Segment of Ambruticin

Document Type

Article

Publication Date

10-2004

Source Publication

Synlett

Abstract

The ruthenium-catalyzed hydrovinylation of 2,4-dienoates 3 proceeds in a regioselective fashion to give 4-alkyl-2,5-dienoates 4 in good yields. Olefin cross-metathesis of a vinylcyclopropane with 4e demonstrates a synthetic route to the C10-C18 ­segment of ambruticin.

Comments

Synlett, Issue 7 (2004), pp. 1312-1314. DOI: 10.1055/s-2004-825605