Document Type
Article
Language
eng
Format of Original
9 p.
Publication Date
4-2015
Publisher
Elsevier Inc.
Source Publication
Materials Science and Engineering: C
Source ISSN
0928-4931
Original Item ID
DOI: 10.1016/j.msec.2015.01.041
Abstract
A reduction in the degradation rate of magnesium (Mg) and its alloys is in high demand to enable these materials to be used in orthopedic applications. For this purpose, in this paper, a biocompatible polymeric layer reinforced with a bioactive ceramic made of polycaprolactone (PCL) and bioactive glass (BG) was applied on the surface of Mg scaffolds using dip-coating technique under low vacuum. The results indicated that the PCL-BG coated Mg scaffolds exhibited noticeably enhanced bioactivity compared to the uncoated scaffold. Moreover, the mechanical integrity of the Mg scaffolds was improved using the PCL-BG coating on the surface. The stable barrier property of the coatings effectively delayed the degradation activity of Mg scaffold substrates. Moreover, the coatings induced the formation of apatite layer on their surface after immersion in the SBF, which can enhance the biological bone in-growth and block the microcracks and pore channels in the coatings, thus prolonging their protective effect. Furthermore, it was shown that a three times increase in the concentration of PCL-BG noticeably improved the characteristics of scaffolds including their degradation resistance and mechanical stability. Since bioactivity, degradation resistance and mechanical integrity of a bone substitute are the key factors for repairing and healing fractured bones, we suggest that PCL-BG is a suitable coating material for surface modification of Mg scaffolds.
Recommended Citation
Yazdimamaghani, Mostafa; Razavi, Mehdi; Vashaee, Daryoosh; and Tayebi, Lobat, "Surface Modification of Biodegradable Porous Mg Bone Scaffold Using Polycaprolactone/Bioactive Glass Composite" (2015). School of Dentistry Faculty Research and Publications. 163.
https://epublications.marquette.edu/dentistry_fac/163
Comments
Accepted version. Materials Science and Engineering: C, Vol 49 (April 2015): 436-444. DOI. © 2015 Elsevier. Used with permission.
NOTICE: this is the author’s version of a work that was accepted for publication in Materials Science and Engineering: C. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Materials Science and Engineering: C, Vol 49 (April 2015): 436-444. DOI.