Title

Microfluidic Manipulation of Core/Shell Nanoparticles for Oral Delivery of Chemotherapeutics: A New Treatment Approach for Colorectal Cancer

Document Type

Article

Language

eng

Format of Original

8 p.

Publication Date

6-1-2016

Publisher

Wiley

Source Publication

Advanced Materials

Source ISSN

0935-9648

Abstract

A microfluidics approach to synthesize core–shell nanocarriers with high pH tunability is described. The sacrificial shell protects the core layer with the drugs and prevents their release in the severe pH conditions of the gastrointestinal tract, while allowing for drug release in the proximity of a tumor. The proposed nanoparticulate drug-delivery system is designed for the oral administration of cancer therapeutics.

Comments

Advanced Materials, Vol. 28, No. 21 (June 1, 2016): 4134-4141. DOI.