Microfluidic Manipulation of Core/Shell Nanoparticles for Oral Delivery of Chemotherapeutics: A New Treatment Approach for Colorectal Cancer

Authors

Mohammad Mahdi Hasani-Sadrabadi, Georgia Institute of Technology
Shahrouz Taranejoo, Monash University, Australia
Erfan Dashtimoghadam, Marquette University
Ghasem Bahlakeh, Amirkabir University of Technology-Iran
Fatemeh Sadat Majedi, University of California, Los Angeles
Jules John VanDesarl, École Polytechnique Fédérale de Lausanne (EPFL)
Mohsen Janmaleki, Shahid Beheshti University
Fatemeh Sharifi, Sharif University of Technology
Arnaud Bertsch, École Polytechnique Fédérale de Lausanne (EPFL)
Kerry Hourigan, Monash University, Australia
Lobat Tayebi, Marquette UniversityFollow
Phillippe Renaud, École Polytechnique Fédérale de Lausanne (EPFL)
Karl I. Jacob, Georgia Institute of Technology

Document Type

Article

Language

eng

Format of Original

8 p.

Publication Date

6-1-2016

Publisher

Wiley

Source Publication

Advanced Materials

Source ISSN

0935-9648

Abstract

A microfluidics approach to synthesize core–shell nanocarriers with high pH tunability is described. The sacrificial shell protects the core layer with the drugs and prevents their release in the severe pH conditions of the gastrointestinal tract, while allowing for drug release in the proximity of a tumor. The proposed nanoparticulate drug-delivery system is designed for the oral administration of cancer therapeutics.

Comments

Accepted version. Advanced Materials, Vol. 28, No. 21 (June 1, 2016): 4134-4141. DOI. © 2016 Wiley. Used with permission.

Recommended Citation

Hasani-Sadrabadi, Mohammad Mahdi; Taranejoo, Shahrouz; Dashtimoghadam, Erfan; Bahlakeh, Ghasem; Majedi, Fatemeh Sadat; VanDesarl, Jules John; Janmaleki, Mohsen; Sharifi, Fatemeh; Bertsch, Arnaud; Hourigan, Kerry; Tayebi, Lobat; Renaud, Phillippe; and Jacob, Karl I., "Microfluidic Manipulation of Core/Shell Nanoparticles for Oral Delivery of Chemotherapeutics: A New Treatment Approach for Colorectal Cancer" (2016). School of Dentistry Faculty Research and Publications. 177.
https://epublications.marquette.edu/dentistry_fac/177