Document Type

Article

Language

eng

Format of Original

9 p.

Publication Date

9-2010

Publisher

Elsevier

Source Publication

Magnetic Resonance Imaging

Source ISSN

0730-725X

Original Item ID

doi: 10.1016/j.mri.2010.03.035

Abstract

Arterial spin labeling techniques can yield quantitative measures of perfusion by fitting a kinetic model to difference images (tagged-control). Because of the noisy nature of the difference images investigators typically average a large number of tagged versus control difference measurements over long periods of time. This averaging requires that the perfusion signal be at a steady state and not at the transitions between active and baseline states in order to quantitatively estimate activation induced perfusion. This can be an impediment for functional magnetic resonance imaging task experiments. In this work, we introduce a general linear model (GLM) that specifies Blood Oxygenation Level Dependent (BOLD) effects and arterial spin labeling modulation effects and translate them into meaningful, quantitative measures of perfusion by using standard tracer kinetic models. We show that there is a strong association between the perfusion values using our GLM method and the traditional subtraction method, but that our GLM method is more robust to noise.

Comments

Accepted version. Magnetic Resonance Imaging, Vol.28, No. 7 (September 2010). DOI. © Elsevier 2010. Used with permission.

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