A Compartmentalized Approach to the Assembly of Physical Maps [Conference Proceedings]
Format of Original
Institute of Electrical and Electronics Engineers (IEEE)
Proceedings of the 7th IEEE International Conference on Bioinformatics and Bioengineering (BIBE) 2007
Original Item ID
We propose a novel compartmentalized method for the assembly of physical maps from fingerprinted clones. Our assembler exploits the presence of genetic markers at the global level to improve the accuracy of the assembly. Experimental results on the genome of rice and barley demonstrate that the compartmentalized assembler produces significantly more accurate maps, and that it can detect and isolate clones that induce chimeric contigs.