Date of Award

Spring 1999

Degree Type

Thesis - Restricted

Degree Name

Master of Science (MS)

Department

Chemistry

First Advisor

Tran, Chieu D.

Second Advisor

Haworth, Daniel T.

Third Advisor

Hoffman, Norman E.

Abstract

Chiral separation remains one of the most challenging tasks in analytical chemistry. Enantiomers of chiral drugs often exhibit different pharmacological and toxicological properties, and this knowledge prompts the demand for a fast, reliable separation approach. In the past, high performance liquid chromatography (HPLC) and gas chromatography (GC) were widely used for chiral separations. Capillary electrophoresis (CE) has been increasingly used since the 1980's and seems to be a promising alternative separation technique due to the advantages of high efficiency and short analysis time. However the number of available chiral selectors is limited. The objective of this thesis is to explore new surfactants and cyclooligosaccharides as chiral selectors for CE chiral separation. At the same time, the results will provide insight into the mechanism of CE chrial separation which to date is not completely understood.

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