Date of Award

Fall 1986

Degree Type

Thesis - Restricted

Degree Name

Master of Science (MS)

Department

Biology

Abstract

The purpose of this investigation is to characterize the association of heterogenous nuclear RNA with nuclear RNA-binding proteins in order to determine what functional roles these proteins may play in modulating mRNA biosynthesis. Two general questions are addressed regarding the specificity in which hnRNA is assembled into ribonucleoprotein complexes. Firstly, are all heterogenous nuclear RNA transcripts assembled into identical ribonucleoprotein complexes or are different RNA molecules packaged differently? Secondly, how are RNA-protein complexes distributed along a particular precursor mRNA transcript?

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