Simulation of the Segmental Burst Generating Network for Locomotion in Lamprey
Format of Original
Recently a segmental network of inhibitory and excitatory interneurones, which are active during locomotion, has been described in the lamprey, a lower vertebrate. The interactions between the different neurones were established by paired intracellular recordings. A computer simulation of the segmental network has been performed, which shows that with the established neuronal connectivity rhythmic alternating burst activity can be generated within the upper part of the normal physiological range of locomotion. Three neurones of each kind were used (altogether 18 neurones). As shown previously the lower frequency range used in locomotion most likely depends on an activation of voltage-dependent (NMDA) receptors, which could, however, not be simulated with the present neuronal models.
Grillner, Stan; Buchanan, James T.; and Lansner, A., "Simulation of the Segmental Burst Generating Network for Locomotion in Lamprey" (2014). Biological Sciences Faculty Research and Publications. 186.