Format of Original
Molecular Reproduction and Development
Regulation of maturation in meiotically competent mammalian oocytes is a complex process involving the carefully coordinated exchange of signals between the somatic and germ cell compartments of the ovarian follicle via paracrine and cell–cell coupling pathways. This review highlights recent advances in our understanding of how such signaling controls both meiotic arrest and gonadotropin-triggered meiotic resumption in competent oocytes and relates them to the historical context. Emphasis will be on rodent systems, where many of these new findings have taken place. A regulatory scheme is then proposed that integrates this information into an overall framework for meiotic regulation that demonstrates the complex interplay between different follicular compartments.
Downs, Stephen, "Regulation of the G2/M Transition in Rodent Oocytes" (2010). Biological Sciences Faculty Research and Publications. 295.
Accepted version. Molecular Reproduction and Development, Vol. 77, No. 7 (July 2010): 566-585. DOI. © 2010 Wiley. This article may be used for non-commercial purposes in accordance With Wiley Terms and Conditions for self-archiving.