Format of Original
Georg Thieme Verlag
Hormone and Metabolic Research
Original Item ID
doi: 10.1055/s-0028-1092729; Shelves: QP 801 .H7 H65 Mem Lvl Lower
Cytochrome oxidase, glycerol-3-phosphate dehydrogenase, and succinate dehydrogenase were measured in mitochondrial fractions obtained from rat soleus muscle of control and 8 week T3 + T4 treated animals. Under these conditions of prolonged treatment, there is a five-fold increase in the specific activities of both cytochrome oxidase and glycerols-3-phosphate dehydrogenase. Significant increases in total cellular mitochondrial content and enzyme activities were observed in T3 + T4 treated animals as compared to controls. These results indicate that thyrotoxicosis can induce selective changes in mitochondrial enzymes in slow twitch red (Type I) muscle fibers.
Courtright, James B. and Fitts, Robert H., "Effects of Thyrotoxicosis on Mitochondrial Enzymes of Rat Soleus" (1979). Biological Sciences Faculty Research and Publications. 490.