Document Type

Conference Proceeding

Language

eng

Format of Original

9 p.

Publication Date

2-15-2003

Publisher

Society of Photo-Optical Instrumentation Engineers

Source Publication

Proceedings of SPIE 5031: Medical Imaging 2003: Physiology and Function: Methods, Systems, and Applications, San Diego, CA, (February 15, 2003)

Original Item ID

doi: 10.1117/12.485800

Abstract

To study the relationship between transpulomnary [sic] pressure (Ptp), intravascular pressure (Pv), and the pulmonary arterial tree structure, morphometric measurements of pulmonary arterial trees were made in intact lungs from Sprague-Dawley rats. Using cone beam micro-CT and techniques we developed for imaging small animal lungs, volumetric CT data were acquired for Ptp from 0 - 12 mmHg and Pv from 5 - 30 mmHg. The diameter, D (measured range approximately 0.08-2.0 mm), vs. pressure, P, relation can be described by D(P) = D(0)(1+ α P), where α is a distensibility coefficient. Unlike studies performed in larger animals, where changes in either Ptp or Pv had nearly identical effect on vessel distensibility, we found that there is only a small dependence of arterial diameter on Ptp in the rat. For example, using the above relation where P=Ptp and Pv is held constant at 12mmHg, alpha = 0.55±0.42(SE) %/mmHg, compared with when P=Pv and Ptp is held at 12mmHg, alpha = 2.59±0.17(SE) %/mmHg.

Comments

Published version. Published as part of the proceedings of the conference, SPIE 5031, Medical Imaging 2003: Physiology and Function: Methods, Systems, and Applications, 2003: 195-203. DOI. © 2003 Society of Photo-optical Instrumentation Engineers (SPIE). Used with permission.

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