Title

Evaluation of 70/30 D,L-PLa for Use as a Resorbable Interbody Fusion Cage

Document Type

Article

Language

eng

Publication Date

10-2002

Publisher

Slack Incorporated

Source Publication

Orthopedics

Source ISSN

0147-7447

Abstract

Titanium lumbar interbody spinal fusion devices are reported to be 90% effective for single-level lumbar interbody fusion, although radiographic determination of fusion has been debated. Using blinded radiographic, biomechanic, histologic, and statistical measures, researchers in the present study evaluated a radiolucent 70/30 poly(L-lactide-co-D,L-lactide) (70/30 D,L-PLa) interbody fusion device packed with autograft or rhBMP-2 on a collagen sponge in 25 sheep at 3, 6, 12, 18, and 24 months. A trend of increased fusion stiffness, radiographic fusion, and histologic fusion was demonstrated from 3 months to 24 months. Device degradation was associated with a mild to moderate chronic inflammatory response at all postoperative sacrifice times.

Comments

Orthopedics, Vol. 25, No. 10 (October 2002): S1131-S1140 . Permalink.

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