Interactions of Triethyltin Bromide with Components of the Red Cell

Document Type

Article

Publication Date

3-30-1981

Publisher

Elsevier

Source Publication

Toxicology and Applied Pharmacology

Source ISSN

0041-008X

Original Item ID

DOI: 10.1016/0041-008X(81)90116-2

Abstract

Triethyltin bromide interacts with the cat hemoglobin and increases its oxygen affinity. The bound complex was visualized by isoelectric focusing on acrylamide gels. Human and trout hemoglobins showed no evidence of interaction with the reagent when examined in the same way. Triethyltin bromide was found, however, to cause hemolysis of trout, cat, and human red cells at physiological temperatures. The hemolytic effect was associated with inhibition of glycolysis as well as of membrane ATPase. Inhibition of glycolysis was identified with selective inhibition of hexokinase. Thus, in addition to cat hemoglobin, hexokinase and membrane ATPase are identified as red cell components that demonstrate functional consequences of interaction with triethyltin bromide. These three proteins are among the few that are known to bind the reagent.

Comments

Toxicology and Applied Pharmacology, Vol. 58, No. 1 (March 30, 1981): 67-75. DOI.

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