A Synthetic Model of the Putative Fe(II)-Iminobenzosemiquinonate Intermediate in the Catalytic Cycle of o-Aminophenol Dioxygenases
Format of Original
American Chemical Society
Journal of the American Chemical Society
Original Item ID
The oxidative ring cleavage of aromatic substrates by nonheme Fe dioxygenases is thought to involve formation of a ferrous–(substrate radical) intermediate. Here we describe the synthesis of the trigonal-bipyramdial [sic] complex Fe(Ph2Tp)(ISQtBu) (2), the first synthetic example of an iron(II) center bound to an iminobenzosemiquinonate (ISQ) radical. The unique electronic structure of this S = 3/2 complex and its one-electron oxidized derivative (+) have been established on the basis of crystallographic, spectroscopic, and computational analyses. These findings further demonstrate the viability of Fe2+–ISQ intermediates in the catalytic cycles of o-aminophenol dioxygenases.
Bittner, Michael M.; Lindeman, Sergey V.; and Fiedler, Adam T., "A Synthetic Model of the Putative Fe(II)-Iminobenzosemiquinonate Intermediate in the Catalytic Cycle of o-Aminophenol Dioxygenases" (2012). Chemistry Faculty Research and Publications. 386.