Charge Transfer in the Mechanism of Drug Action Involving Quinoxaline Di-N-Oxides

Authors

Michael D. Ryan, Marquette UniversityFollow
Richard G. Scamehorn, University of Wisconsin - MilwaukeeFollow
Peter Kovacic, University of Wisconsin - MilwaukeeFollow

Document Type

Article

Language

eng

Format of Original

4 p.; 26 cm

Publication Date

4-1985

Publisher

Wiley

Source Publication

Journal of Pharmaceutical Sciences

Source ISSN

0022-3549

Abstract

Cyclic voltammetry data were obtained for various 2,3‐disubstituted quinoxaline di‐N‐oxides: dimethyl, bishydroxymethyl, bisacetoxymethyl, bis‐N‐anilinomethyl, and dicarboxaldehyde hydrate. The dimethyl derivative exhibited the most negative E_1/2 value, and along with the diol, showed reversible reduction for the first wave. Rationalizations of the E_1/2 values are provided. Reasonable correlations exist for the electrochemical data and drug activity. The results support the diiminium theory of drug action.

Comments

Journal of Pharmaceutical Sciences, Vol. 74, No. 4 (April 1985): 492-495. DOI.

Recommended Citation

Ryan, Michael D.; Scamehorn, Richard G.; and Kovacic, Peter, "Charge Transfer in the Mechanism of Drug Action Involving Quinoxaline Di-N-Oxides" (1985). Chemistry Faculty Research and Publications. 439.
https://epublications.marquette.edu/chem_fac/439