Mechanism of Antibacterial Action: Electron Transfer and Oxy Radicals
Format of Original
Free Radical Biology and Medicine
Most of the main categories of bactericidal agents, namely, aliphatic and heterocyclic nitro compounds, metal derivatives and chelators, quinones, azo dyes, and iminium-type ions, are proposed to exert their action by a unified mechanism. The toxic effect is believed to result generally from the catalytic production of reactive oxygen radicals that usually arise via electron transfer. Cyclic voltammetry was performed on a number of these agents. Reductions were for the most part reversible, with potentials in the favorable range of −0.20 to −0.58 V.
Ames, James R.; Ryan, Michael D.; and Kovacic, Peter, "Mechanism of Antibacterial Action: Electron Transfer and Oxy Radicals" (1986). Chemistry Faculty Research and Publications. 441.