Charge Transfer-Oxy Radical Mechanism for Anticancer Agents: mAMSA Derivatives, Rhodamine 123, and Nickel Salicylaldoximate

Authors

Philip W. Crawford, Marquette University
Paavo Lumme, University of Helsinki
Hannu Elo, University of Helsinki
Michael D. Ryan, Marquette UniversityFollow
Peter Kovacic, University of Wisconsin - Milwaukee

Document Type

Article

Language

eng

Format of Original

10 p.

Publication Date

1987

Publisher

Taylor & Francis

Source Publication

Free Radical Research Communications

Source ISSN

8755-0199

Original Item ID

doi.10.3109/10715768709088075

Abstract

The proposal is advanced that many anticancer agents may function via redox reactions resulting in generation of toxic oxy radicals which destroy neoplastic cells. Cyclic voltammetry was performed with some of the main types: iminium ions (protonated mAMSA derivatives), quinone derivatives (rhodamine 123) and metal complexes (nickel(II) salicylaldoximate). In addition, relevant literature data are provided. A rationale is offered that relates electrochemical data to physiological activity.

Comments

Free Radical Research Communications, Vol. 3, No. 3 (1987): 347-356. DOI.

Recommended Citation

Crawford, Philip W.; Lumme, Paavo; Elo, Hannu; Ryan, Michael D.; and Kovacic, Peter, "Charge Transfer-Oxy Radical Mechanism for Anticancer Agents: mAMSA Derivatives, Rhodamine 123, and Nickel Salicylaldoximate" (1987). Chemistry Faculty Research and Publications. 507.
https://epublications.marquette.edu/chem_fac/507