The C11–C17 segment of the antifungal agent soraphen A1α was prepared from glyceraldehyde acetonide in nine steps. The C12 stereocenter is derived from glyceraldehyde, while the C17 stereocenter as introduced by 1,6-asymmetric control via the coordinated Fe(CO)3.
The C11–C17 segment of the antifungal agent soraphen A1α, with required inverted stereochemistry at C17, was prepared. The C12 stereocenter is derived from glyceraldehyde, while the C17 stereocenter is introduced by 1,6-asymmetric induction via a coordinated Fe(CO)3.
Cao, Yeyu; Eweas, Ahmad F; and Donaldson, William, "Enantioselective synthesis of the C11–C17 segment of soraphen A1α via organoiron methodology" (2002). Chemistry Faculty Research and Publications. 66.
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