Enantioselective synthesis of the C11–C17 segment of soraphen A1α via organoiron methodology

Authors

Yeyu Cao, Marquette UniversityFollow
Ahmad F Eweas, Marquette University
William Donaldson, Marquette UniversityFollow

Document Type

Article

Publication Date

10-2002

Publisher

Elsevier

Source Publication

Tetrahedron Letters

Source ISSN

0040-4039

Abstract

The C11–C17 segment of the antifungal agent soraphen A_1α was prepared from glyceraldehyde acetonide in nine steps. The C12 stereocenter is derived from glyceraldehyde, while the C17 stereocenter as introduced by 1,6-asymmetric control via the coordinated Fe(CO)₃.

The C11–C17 segment of the antifungal agent soraphen A1α, with required inverted stereochemistry at C17, was prepared. The C12 stereocenter is derived from glyceraldehyde, while the C17 stereocenter is introduced by 1,6-asymmetric induction via a coordinated Fe(CO)₃.

Comments

Accepted version. Tetrahedron Letters, Vol. 43, Issue 43 (2002), pp 7831-7834. DOI: 10.1016/S0040-4039(02)01727-6. © 2002 Elsevier. Used with permission.

Recommended Citation

Cao, Yeyu; Eweas, Ahmad F; and Donaldson, William, "Enantioselective synthesis of the C11–C17 segment of soraphen A1α via organoiron methodology" (2002). Chemistry Faculty Research and Publications. 66.
https://epublications.marquette.edu/chem_fac/66