Immunohistochemical Expression of TLR-4 in Temporomandibular Joint Dysfunction
Taylor & Francis
CRANO: Journal of Craniomandibular & Sleep Practice
Toll-like receptor 4 (TLR-4) is a transmembrane protein involved in the innate immune system and has been implicated in the pathogenesis of temporomandibular joint dysfunction (TMD). The purpose of this study was to histologically examine the level of expression of TLR-4 relative to severity of TMD.
Thirty-one human TMJ disc samples were immunostained for TLR-4 and evaluated for intensity of stain. Among the samples, 8 were control samples, 16 were from patients with anterior disc displacement with reduction (ADDwR), and 7 were from patients with anterior disc displacement without reduction (ADDwoR).
There was no statistically significant difference in intensity of stain between groupings (p = 0.673).
The results indicate a negative correlation between TMD and the expression of TLR-4.