Title

Immunohistochemical Expression of TLR-4 in Temporomandibular Joint Dysfunction

Document Type

Article

Language

eng

Publication Date

4-2018

Publisher

Taylor & Francis

Source Publication

CRANO: Journal of Craniomandibular & Sleep Practice

Source ISSN

0886-9634

Abstract

Objective

Toll-like receptor 4 (TLR-4) is a transmembrane protein involved in the innate immune system and has been implicated in the pathogenesis of temporomandibular joint dysfunction (TMD). The purpose of this study was to histologically examine the level of expression of TLR-4 relative to severity of TMD.

Methods

Thirty-one human TMJ disc samples were immunostained for TLR-4 and evaluated for intensity of stain. Among the samples, 8 were control samples, 16 were from patients with anterior disc displacement with reduction (ADDwR), and 7 were from patients with anterior disc displacement without reduction (ADDwoR).

Results

There was no statistically significant difference in intensity of stain between groupings (p = 0.673).

Conclusions

The results indicate a negative correlation between TMD and the expression of TLR-4.

Comments

CRANIO: The Journal of Carniomandibular & Sleep Practice, (2018). DOI.

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