Taylor & Francis
CRANO: Journal of Craniomandibular & Sleep Practice
Temporomandibular joint dysfunction (TMD) may affect a patient’s quality of life, and one of the etiologies can be anterior disc displacement with reduction (ADDwR) and anterior disc displacement without reduction (ADDWoR). Interleukin 1 Receptor 1 (IL-1R1) is a membrane receptor that plays an important role on initiating immune and inflammatory response by binding the agonists ligands of IL-1 alpha and IL-1 beta. Therefore, the aim of this study was to evaluate, through immunohistochemical analysis, the association of IL-1R1 with TMD.
Thirty-nine human disc samples were collected and composed three different groups: ADDwR (n = 19), ADDwoR (n = 12), and control group (n = 8). The samples were immunostained with IL-1R1 antibody and evaluated on both quantity and intensity of staining.
There was a statistically significant difference (p < 0.05) between the control and test groups for both quantity and intensity of staining.
IL1-R1 was associated with ADDwR and ADDwoR in TMD discs of humans.
Almeida, Luis Eduardo; Sorenson, Adam; Hresko, Kyle; Butcher, Seth; Leonardi, Rosalia; Lorento, Carla; Bosio, Jose A.; Tayebi, Lobat; and Doetzer, Andrea, "Immunohistochemical Analysis of IL-1 Receptor 1 In the Discs of Patients with Temporomandibular Joint Dysfunction" (2018). School of Dentistry Faculty Research and Publications. 278.