Document Type




Publication Date




Source Publication

Journal of Oral Pathology & Medicine

Source ISSN



Background: Internal derangement is the most frequent arthropathy affecting the temporomandibular joint, where its commonest form is anterior disc displacement with or without reduction. Despite the frequency of the disorder, the biochemical features of displaced discs are still unclear.

Methods: We investigated the expression pattern and localization of aquaporin‐1, an important channel protein involved in plasma membrane water permeability, in patients with anterior disc displacement (both with and without reduction), with a view to assessing the characteristics of local tissue responses to the microenvironmental changes induced by abnormal mechanical loading of the displaced disc. Protein expression was studied by immunohistochemistry in different areas of discs from 18 patients with anterior disc displacement with or without reduction and in four normal controls.

Results: A greater proportion of cells immunopositive for aquaporin‐1 were detected in diseased than in normal discs. Whereas protein expression was substantially similar in the different areas of normal discs, a significantly larger number of immunopositive cells were detected in the posterior band of displaced discs without reduction and in the anterior and intermediate bands of those with reduction.

Conclusions: These findings suggest that aquaporin‐1 is expressed and upregulated in temporomandibular joint with anterior disc displacement (both with and without reduction).


Accepted version. Journal of Oral Pathology & Medicine, Vol 41, No. 8 (September 2012): 642-647. DOI. © 2012 John Wiley & Sons, Inc. Used with permission.

Luis Eduardo Almeida was affiliated with Center for Health and Biological Sciences, Pontifical Catholic, University of Panarà, Curitibe, Brazil at the time of publication.

almeida_12727acc.docx (283 kB)
ADA accessible version

Included in

Dentistry Commons