Materials Science and Engineering : C
This paper describes the design of stimuli-sensitive theranostic nanoparticles, composed of reduced graphene oxide (rGO) self-assembled on thermosensitive liposomes encapsulated doxorubicin (DOX) and carbon quantum dot (CQD) (CQD-DOX-rGO-Tlip). The rGO-Tlip particles have been observed to be flower-shaped objects. The thermoresponsive and theranostic potential of CQD-DOX-rGO-Tlips have been studied using differential scanning calorimetry (DSC), ultraviolet visible spectroscopy (UV–Vis), Raman spectroscopy and photoluminescent assays. The chemo-photothermal potential of rGO–Tlip on MD-MB-231 cells during NIR laser irradiation has been examined using MTT assay. Also, the ability of rGO–Tlip to be taken up by MD-MB-231 cells has been studied using confocal microscopy and flowcytometry. The results indicate that CQD-DOX-rGO-Tlips achieve a synergistic effect between photothermal therapy and chemotherapy for cancer treatment. Furthermore, online monitoring drug release is accomplished by studying the emission intensity of CQD while DOX released.
Hashemi, Mohadeseh; Mohammadi, Javad; Omidi, Meisam; Smyth, Hugh D.C.; Muralidharan, Bharadwaj; Milner, Thomas E.; Yadegari, Amir; Ahmadvand, Davoud; Shalbaf, Mohammad; and Tayebi, Lobat, "Self-Assembling of Graphene Oxide on Carbon Quantum Dot Loaded Liposomes" (2019). School of Dentistry Faculty Research and Publications. 355.
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