Date of Award

Spring 2004

Document Type

Dissertation - Restricted

Degree Name

Doctor of Philosophy (PhD)



First Advisor

Donaldson, William A.

Second Advisor

Steinmetz, Mark G.

Third Advisor

Kincaid, James J.


In recent years complex natural products produced by microorganisms have given a great challenge to the synthetic organic chemist. Soraphen A1a is the parent compound of a family of macrolides discovered by the research group of Reichenbach and Hofle. Soraphen A1a was found to be a highly potent antifungal antibiotic against a variety of phytopathogenic fungi. The use of tricarbonyl iron complexes had been recognized as powerful stereo directing tool in organic synthesis.



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