Date of Award
9-1964
Document Type
Dissertation - Restricted
Degree Name
Doctor of Philosophy (PhD)
Department
Medical
First Advisor
Howard M. Klitgaard
Abstract
A number of the physiological actions of thyroxine have been characterized, but in each instance, the mechanism eliciting these actions is unknown. An explanation for the action of the thyroid hormones has been sought at the level of the whole organism, of organs, tissues, cells, and more recently, at the subcellular level. Two prominent hypotheses concerning thyroid hormone action involve effects on enzymes and enzyme systems (in particular the oxidative enzymes) and on membrane permeability. No definitive concept of the mode of action of thyroxine has evolved from information gained either in the multitude of enzyme studies or investigations of thyroxine-dependent changes in membrane permeability.
Comments
A Dissertation Submitted to the Faculty of the Graduate School, Marquette University in Partial Fulfillment of the Requirements for the Degree of Doctor of Philosophy Milwaukee, Wisconsin