Date of Award
1969
Document Type
Dissertation - Restricted
Degree Name
Doctor of Philosophy (PhD)
Department
Medical
First Advisor
Deane N. Calvert
Second Advisor
Ronald Kalkloff
Third Advisor
Harold F. Hardman
Abstract
While it had been suspected for a long time that adipose tissue was under the control of the sympathetic nervous system the first definitive evidence that nerepinephrine is a normal constituent of adipose tissue was reported just 8 years ago. The neurehormone was found to be present in amounts far in excess of those needed for circulatory function, and was felt to be localized in adrenegic nerve endings since it was readily depleted by reserpine. The concentrations of norepinephrine, expressed per milligram of protein, are similar to those of heart and brain, indicating that the tissue is richly innervated by sympathetic nerves. The sympathetic nerves in adipose tissue readily take up 3H-norepinephrine. Brown adipose tissue of mice and rats also contains particularly large amounts of norepinephrine.
Comments
A Dissertation submitted to the faculty of the Graduate School, Marquette University, in partial fulfillment of the requirements for the Degree of Doctor of Philosophy, Milwaukee, Wisconsin