Document Type

Conference Proceeding

Language

eng

Format of Original

4 p.

Publication Date

10-28-2012

Publisher

Institute of Electrical and Electronics Engineers

Source Publication

2012 IEEE Sensors Proceedings

Source ISSN

1930-0395

Original Item ID

doi: 10.1109/ICSENS.2012.6411338

Abstract

This work presents a cantilever-based mass-sensitive microsensor platform for the detection of biomolecules in the liquid phase. The resonant microstructures feature integrated thermal excitation and piezoresistive detection elements to excite and sense the structure's fundamental in-plane flexural mode. A gold film on the cantilevers allows for the local immobilization of biomolecules using gold-thiol chemistry. Using the in-plane flexural mode, quality factors of the order of 30-50 are obtained in water at resonance frequencies around 500 kHz. The reduced liquid damping enables closed-loop operation of the resonators with frequency stabilities in the ppm-range. Using a microfabricated flow cell, anti-IgG is detected in PBS with limits of detection on the order of 50 ng/ml.

Comments

Accepted version. Published as part of the proceedings of the conference, IEEE Sensors, 2012. DOI. © 2012 Institute of Electrical and Electronics Engineers (IEEE). Used with permission.

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