A Chromatographic, Autoradiographic and Actigraphic Analysis of Thyroxine Metabolites in Rat Tissues And Their Correlation With Oxygen Consumption Values
A Thesis submitted to the Faculty of the Graduate School, Marquette University in Partial Fulfillment of the Requirements for the Degree of Master of Science, Milwaukee, Wisconsin.
Abstract
The intellectual calm that prevailed in thyroid physiology on the basis of the concept that thyroxine was the thyroid hormone, was upset by the discovery and characterization of a new thyroid hormone in 1951 and 1952. In a brilliant series of experiments this new substance, triiodothyronine, was found to be more potent and its action more rapid than thyroxine. Such observations had a salutary effect on thyroid physiology and stimulated a ferment of investigation of far-reaching consequence. Other thyroactive analogues of thyroxine and triiodothyronine have since been studied in an effort to elucidate the nature and mode of action of the thyroid hormone or hormones.