Conjugated Linoleic Acid Preserves Muscle Mass in Mice Bearing the Lewis Lung Carcinoma, but not the B16 Melanoma
Format of Original
Research in Nursing and Health
Original Item ID
doi: 10.1002/nur.20115; Shelves: RT1 .R48x Raynor Memorial Periodicals
Conjugated linoleic acid (CLA), which is found in dairy products, reduces synthesis of tumor necrosis factor-alpha (TNFa), a pro-inflammatory cytokine that plays a major role in tumor-induced skeletal muscle wasting (SMW). The B16 melanoma expresses TNFa mRNA, and induced SMW with no change in muscle levels of TNFa type 1 receptor (TNFR1) protein. A diet containing .5% CLA had no effect on SMW or TNFR1 in mice bearing B16 tumors. In contrast, the Lewis lung carcinoma expresses low levels of TNFa mRNA, induced SMW, and increased muscle levels of TNFR1. A diet containing .5% CLA reduced SMW, but had no effect on muscle levels of TNFR1. We conclude that that tumor-induced SMW can occur independent of muscle levels of TNFR1. Further study is needed before CLA can be tested in persons with cancer cachexia. © 2006 Wiley Periodicals, Inc. Res Nurs Health 29:98–104, 2006
McCarthy, Donna O. and Graves, Erin, "Conjugated Linoleic Acid Preserves Muscle Mass in Mice Bearing the Lewis Lung Carcinoma, but not the B16 Melanoma" (2006). College of Nursing Faculty Research and Publications. 190.