Indomethacin and Ibuprofen Preserve Gastrocnemius Muscle Mass in Mice Bearing the Colon26 Adenocarcinoma
Format of Original
Research in Nursing and Health
Original Item ID
doi: 10.1002/nur.20019; Shelves: RT1 .R48x Raynor Memorial Periodicals
Skeletal muscle wasting is a prominent feature of cancer cachexia and involves decreased muscle protein synthesis and increased activity of the ubiquitin-proteasome pathway of protein degradation. We report that both indomethacin and ibuprofen improved body weight and weight of the gastrocnemius muscle in tumor-bearing mice. Ibuprofen increased the soluble protein content of the muscle without affecting muscle levels of phosphorylated p70 S6 kinase, a ribosomal kinase involved in protein synthesis. Paradoxically, indomethacin increased levels of ubiquitin-conjugated proteins. Further study is needed to understand the mechanism of action by which indomethacin and ibuprofen preserve body weight and muscle mass in the tumor-bearing mice. The data suggest that ibuprofen may have beneficial effects in the treatment of cancer cachexia. © 2004 Wiley Periodicals, Inc. Res Nurs Health 27:174–184, 2004
McCarthy, Donna O.; Whitney, Pamela; Hitt, Andrew; and Al-Majid, Sadeeka, "Indomethacin and Ibuprofen Preserve Gastrocnemius Muscle Mass in Mice Bearing the Colon26 Adenocarcinoma" (2004). College of Nursing Faculty Research and Publications. 193.