The Role of Gastric Stasis in Tumor-Induced Anorexia in Rats
Format of Original
Original Item ID
Background. The current study was undertaken to determine if changes in gastric emptying contribute to tumor-induced anorexia.
Methods. Rats were implanted with the Walker 256 carcinoma, and food intake was measured daily. On days 0, 8, and 15, the rats were fasted overnight, gavage fed a bolus of liquid food, and residual gastric contents were measured 3 hours later.
Results. Tumor growth was associated with a progressive decline in voluntary food intake. When the rats were gavage fed 2.5 or 7 ml of liquid food, the percent of gastric contents cleared in 3 hours was unchanged with tumor growth.
Conclusions. Changes in gastric emptying did not contribute to decreased food intake with growth of the Walker 256 in rats.