Title

Suppression of Food Intake During Infection: Is Interleukin-1 Involved?

Document Type

Article

Language

eng

Format of Original

4 p.

Publication Date

12-1985

Publisher

American Society for Nutrition

Source Publication

American Journal of Clinical Nutrition

Source ISSN

0002-9165

Abstract

Loss of food appetite is a common manifestation of acute infectious illness and is believed to contribute to the negative nitrogen balance and loss of body weight that is seen during infection. The frequency with which anorexia occurs with infection suggests that it may be part of the acute phase response. In the present experiments, food intake of fasted rats was suppressed following injection of interleukin-1, a polypeptide that mediates many host responses to infection. We conclude that infection-induced anorexia is, in part, due to the release of interleukin-1.

Comments

American Journal of Clinical Nutrition, Vol. 42, No. 6 (1985, December): 1179-1182. Permalink.

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