Date of Award

Summer 1964

Degree Type

Thesis - Restricted

Degree Name

Master of Science (MS)



First Advisor

Smith, James J.

Second Advisor

Glenestes, David W.

Third Advisor

Stekiel, William J.


The reticuloendothelial system (RES) which is widespread in distribution and associated with diversified functions consists of a collection of cells among whose measurable characteristics is phagocytosis. Although the functional state of the RE cells has often been assessed through its phagocytic capacity, the physicochemical basis of particle ingestion by these cells has received little attention. The significant role played by surface forces in the ingestive phenomenon has been shown and the energy dependence of the process demonstrated in polymorphonuclear leucocytes, monocytes, alveolar (lung) macrophages and other cultured phagocytic cells. The present study was initiated to explore certain aspects of the physicochemical basis of phagocytosis by fixed reticuloendothelial cells - the sinusoidal lining cells of the liver - more commonly referred to as the Kupffer cells.